基因测序应用公司「希望组」完成近亿元 B 轮融资,将发力三代测序技术产品化应用

北京希望组(以下简称“希望组”)近日完成了近 1 亿元人民币B轮融资。本轮融资由远毅资本领投,昌平科技产业母基金(昌发展管理基金)和老股东经纬中国跟投。浩悦资本担任本次交易独家财务顾问。2016 年底,团队完成了由经纬中国主领投、赛富投资共领投、清科创投跟投的 A 轮融资。

此轮融资之后,希望组将加大平台和研发的投入,推进三代测序技术在遗传病领域的临床应用落地以及加强与上游企业合作,将三代测序技术和临床应用产品化。

基因测序是一种新型基因检测技术,能够从血液或唾液中分析测定基因全序列,预测罹患多种疾病的可能性。近年间,基因测序从实验室走入临床,国际上最著名的例子便是安吉丽娜·朱莉曾采用基因测序,并为了抵御癌症的侵袭,预防性地切除自己的乳腺。其余的常见应用场景,便是唐氏综合征筛查的无创产前基因检测。

从 2015 年开始,希望组在三代测序技术应用于遗传病检测、肿瘤诊断、辅助生殖、微生物组等领域进行了研发和知识产权积累,进而为全球科研及临床用户提供基因组学解决方案的产品和服务。

沃森和克里克在1953年建立DNA双螺旋结构以来,整个测序技术的发展历程。图源:CSDN

以 PacBio 公司的 SMRT 和 Oxford Nanopore Technologies 纳米孔单分子测序技术,被称之为第三代测序技术。与前两代相比,他们最大的特点就是单分子测序,测序过程无需进行PCR扩增。具体来讲,相对于二代,三代测序的优势主要在于:

  • 其读长可达到二代测序的100倍以上,且无CG偏好的优势,甚至可以直接检测DNA/RNA上的碱基修饰。

  • 随着PacBio 和ONT技术平台的发展,以及相应配套生物信息分析水平的提升,已经有效克服了单次读序错误率的问题,在单碱基变异(SNVs)、结构变异(SVs)、甲基化修饰(Methylation)等领域,已经可以广泛应用。

  • 随着 ONT 最新测序仪 PromethION 的推出,测序成本较目前出现指数级的降低,测序通量将呈1000 倍以上的比例增长。

希望组医学科研业务线负责人、市场部副总余国亮:二代测序技术目前的市场占额大概在 80% 左右,他提到,虽然就目前来看,第二代短读长测序技术在全球测序市场上占有绝对的优势,但随着上游公司测序仪的升级,预计在未来的 1 年(甚至更短的时间内)三代测序的价格有望与二代的价格相当,甚至便宜1/2,因此,三代技术能够被迅速推广。

而作为一个新技术,第三代测序的不足之处在于:

  1. 单读长的错误率依然偏高,第三代基因测序技术目前的错误率在15%-40%,极大地高于二代测序技术NGS的错误率(低于1%)。这也成为限制其商业应用开展的原因之一。

  2. 三代测序技术依赖DNA聚合酶的活性。

  3. 成本较高,二代Illumina的测序成本是每100万个碱基0.05-0.15美元,三代测序成本是每100万个碱基0.33-1.00美元。

  4. 生信分析软件也不够丰富。

对于以上几点,希望组王凯教授课题组开发了 NanoMod,通过分析原始信号中的强度特征,改善DNA修饰检测的分析,从而提高碱基修饰信息识别的准确度。

现阶段,测序的数据源主要来源于医院。

希望组集团拥有“未来组”(基地在武汉)和“希望组”(北京)两大品牌,分别面向科研和临床用户。

余国亮表示,在收入增长方面,科研的收入占比更大。这与医学科研的需求分不开,医生作为主要客户群体以申报项目的方式采购未来组的产品,希望使用二代测序无法解释的疑难病例可以用三代测序做到。而临床方面,三代测序的主要客户为各地的三甲医院,大部分产品均为基于临床遗传病的检测。

谈及市场竞争自然躲不开华大基因。余国亮提到,华大作为全平台的公司,三代测序只是其中很小的一部分。而希望组的竞争力在于专注于三代测序,细分领域相比华大更有优势,而其应用场景也比较丰富,除了基因的检测,生信的研发,还有实验的研发与优化。

余国良:希望组目前配备了 20 台 GridION X5、1台 PromethION、6 台PacBio Seque l以及 2 台 Bionano Saphyr平台,是全球为数不多的配置完整三代测序技术平台的公司,同时也是目前中国独家、世界第一批通过 ONT PromethION 官方测序服务认证的公司。

除了华大基因外,目前国内布局三代测序的还有瀚海基因。2015 年,瀚海基因(Direct Genomics)公布了基于 Helicos 技术研发的专门用于临床的第三代单分子测序仪 GenoCare 原理样机。中科院北京基因组研究所与浪潮基因组科学也在共同研制国产第三代基因测序仪。

团队方面。创始人汪德鹏 1997 年从北京大学生物科学学院毕业,历经基因测序行业17年,2014 年与王凯教授一起创立北京希望组,希望组目前的团队组成 180 余人(北京希望组团队 80 多人,武汉未来组100多人)

本文主要内容引自 36氪

365 thoughts on “基因测序应用公司「希望组」完成近亿元 B 轮融资,将发力三代测序技术产品化应用”

  1. Pingback: Lincoln Georgis
  2. Pingback: Leandro Farland
  3. Pingback: Cory Chase MILF City
  4. Pingback: MILF Porn
  5. Pingback: best-domains
  6. Pingback: scar treatment
  7. Pingback: organic sunblock
  8. Pingback: valentine pillow
  9. Pingback: Click Here
  10. Pingback: Click Here
  11. Pingback: Click Here
  12. Pingback: Click Here
  13. Pingback: Click Here
  14. Pingback: Click Here
  15. Pingback: Click Here
  16. Pingback: Click Here
  17. Pingback: Click Here
  18. Pingback: Click Here
  19. Pingback: Click Here
  20. Pingback: Click Here
  21. Pingback: Click Here
  22. Pingback: Click Here
  23. Pingback: Click Here
  24. Pingback: moveit studio
  25. Pingback: robotics case study
  26. Pingback: moveit studio
  27. Pingback: Click Here
  28. Pingback: Click Here
  29. Pingback: Click Here
  30. Pingback: Click Here
  31. Pingback: Reputation Defenders
  32. Pingback: Reputation Defenders
  33. Pingback: Click Here
  34. Pingback: Click Here
  35. Pingback: Click Here
  36. Pingback: Click Here
  37. Pingback: Click Here
  38. Pingback: Click Here
  39. Pingback: Click Here
  40. Pingback: Click Here
  41. Pingback: Click Here
  42. Pingback: Click Here
  43. Pingback: Click Here
  44. Pingback: Click Here
  45. Pingback: Click Here
  46. Pingback: Click Here
  47. Pingback: Click Here
  48. Pingback: grand rapids dentist
  49. Pingback: Click Here
  50. Pingback: Click Here
  51. Pingback: Click Here
  52. Pingback: Click Here
  53. Pingback: Click Here
  54. Pingback: Click Here
  55. Pingback: Click Here
  56. Pingback: Click Here
  57. Pingback: Click Here
  58. Pingback: Click Here
  59. Pingback: Click Here
  60. Pingback: Click Here
  61. Pingback: Click Here
  62. Pingback: Click Here
  63. Pingback: Click Here
  64. Pingback: Referral Program
  65. Pingback: Click Here
  66. Pingback: Click Here
  67. Pingback: Click Here
  68. Pingback: Click Here
  69. Pingback: Click Here
  70. Pingback: Click Here
  71. Pingback: Click Here
  72. Pingback: Click Here
  73. Pingback: domains
  74. Pingback: domain
  75. Pingback: theformationscompany
  76. Pingback: Google reviews
  77. Pingback: reputation defenders
  78. Pingback: 2023 Books
  79. Pingback: search dececased
  80. Pingback: death
  81. Pingback: online memorial
  82. Pingback: IRA Empire
  83. Pingback: betting tips 1x2
  84. Pingback: Chirurgie Tunisie
  85. Pingback: Community engagement
  86. Pingback: Student life
  87. Pingback: Higher education
  88. Pingback: MBA tuition fees
  89. Pingback: Political Mass Media
  90. Pingback: political economy
  91. Pingback: Environmental Policy
  92. Pingback: MSc in pharmacy
  93. Pingback: Research Activities
  94. Pingback: end-of-term exams
  95. Pingback: Values and ethics
  96. Pingback: Academic research
  97. Pingback: Scientific research
  98. Pingback: Personal development
  99. Pingback: Attendance Policy
  100. Pingback: fue contact
  101. Pingback: faculty of dental
  102. Pingback: Network Administrator
  103. Pingback: Pharmacy's PHD
  104. Pingback: Maillot de football
  105. Pingback: Maillot de football
  106. Pingback: Maillot de football
  107. Pingback: Maillot de football
  108. Pingback: Maillot de football
  109. Pingback: Maillot de football
  110. Pingback: Maillot de football
  111. Pingback: Maillot de football
  112. Pingback: Maillot de football
  113. Pingback: Maillot de football
  114. Pingback: Maillot de football
  115. Pingback: Maillot de football
  116. Pingback: Maillot de football
  117. Pingback: SEOSolutionVIP Fiverr
  118. Pingback: SEOSolutionVIP Fiverr
  119. Pingback: led luci camera
  120. Pingback: pull ups
  121. Pingback: squat avec barre
  122. Pingback: cage a squat
  123. Pingback: metanail serum pro
  124. Pingback: Fiverr Earn
  125. Pingback: Fiverr Earn
  126. Pingback: Fiverr Earn
  127. Pingback: Fiverr Earn
  128. Pingback: Fiverr Earn
  129. Pingback: Fiverr Earn
  130. Pingback: Hooled luce led
  131. Pingback: fiverrearn.com
  132. Pingback: fiverrearn.com
  133. Pingback: fiverrearn.com
  134. Pingback: fiverrearn.com
  135. Pingback: fiverrearn.com
  136. Pingback: fiverrearn.com
  137. Pingback: fiverrearn.com
  138. Pingback: fiverrearn.com
  139. Pingback: Advance-Esthetic LLC
  140. Pingback: frenchies in houston
  141. Pingback: fiverrearn.com
  142. Pingback: weather
  143. Pingback: fiverrearn.com
  144. Pingback: chocolate frenchie
  145. Pingback: chiweenie lifespan
  146. Pingback: jute vs sisal rug
  147. Pingback: Digital Marketing
  148. Pingback: London Piano Movers
  149. Pingback: fluffy french bulldog
  150. Pingback: bikini
  151. Pingback: bikini
  152. Pingback: hawaii weather kauai
  153. Pingback: brindle frenchie
  154. Pingback: Cash for phones
  155. Pingback: Custom made bracelet
  156. Pingback: technology
  157. Pingback: future university
  158. Pingback: future university
  159. Pingback: daftar multisbo
  160. Pingback: french bulldogs
  161. Pingback: Fiverr.Com
  162. Pingback: best university Egypt
  163. Pingback: french bulldog
  164. Pingback: Upright piano storage
  165. Pingback: FUE
  166. Pingback: FUE
  167. Pingback: FUE
  168. Pingback: FUE
  169. Pingback: FUE
  170. Pingback: FUE
  171. Pingback: FUE
  172. Pingback: FUE
  173. Pingback: Secure storage
  174. Pingback: Moving assistance
  175. Pingback: FiverrEarn
  176. Pingback: FiverrEarn
  177. Pingback: FiverrEarn
  178. Pingback: FiverrEarn
  179. Pingback: FiverrEarn
  180. Pingback: FiverrEarn
  181. Pingback: FiverrEarn
  182. Pingback: FiverrEarn
  183. Pingback: pupuk cair
  184. Pingback: pupuk terbaik
  185. Pingback: partners
  186. Pingback: Healthcare products
  187. Pingback: frenchie puppies
  188. Pingback: Predictions
  189. Pingback: FiverrEarn
  190. Pingback: FiverrEarn
  191. Pingback: FiverrEarn
  192. Pingback: FiverrEarn
  193. Pingback: live sex cams
  194. Pingback: live sex cams
  195. Pingback: live sex cams
  196. Pingback: FiverrEarn
  197. Pingback: FiverrEarn
  198. Pingback: FiverrEarn
  199. Pingback: FiverrEarn
  200. Pingback: texas french bulldogs
  201. Pingback: FiverrEarn
  202. Pingback: FiverrEarn
  203. Pingback: FiverrEarn
  204. Pingback: FiverrEarn
  205. Pingback: FiverrEarn
  206. Pingback: FiverrEarn
  207. Pingback: FiverrEarn
  208. Pingback: FiverrEarn
  209. Pingback: FiverrEarn
  210. Pingback: FiverrEarn
  211. Pingback: serialebi qaerulad
  212. Pingback: seo company new york
  213. Pingback: technology
  214. Pingback: Scientific Research
  215. Pingback: Kuliah Termurah
  216. Pingback: FiverrEarn
  217. Pingback: FiverrEarn
  218. Pingback: FiverrEarn
  219. Pingback: FiverrEarn
  220. Pingback: red boost legit
  221. Pingback: cheap sex cams
  222. Pingback: canine probiotics
  223. Pingback: live sex cams
  224. Pingback: live sex cams
  225. Pingback: live sex cams
  226. Pingback: live sex cams
  227. Pingback: frt trigger
  228. Pingback: Despacho contable
  229. Pingback: 늑대닷컴
  230. Pingback: Free spin
  231. Pingback: nangs near me
  232. Pingback: superslot
  233. Pingback: allgame
  234. Pingback: 918kiss
  235. Pingback: หวย24
  236. Pingback: Skincare tips
  237. Pingback: pg slot
  238. Pingback: AI Lawyer
  239. Pingback: la bonne paye règle
  240. Pingback: Raahe Guide
  241. Pingback: Raahe Guide
  242. Pingback: catskills hotel
  243. Pingback: apply evisa online
  244. Pingback: weight loss drops
  245. Pingback: ozempic
  246. Pingback: 17 wsm
  247. Pingback: 6.5 grendel ammo
  248. Pingback: SaaS Legal Services
  249. Pingback: itsMasum.Com
  250. Pingback: itsMasum.Com
  251. Pingback: itsMasum.Com
  252. Pingback: omegle for kids
  253. Pingback: talk with strangers
  254. Pingback: joker gaming
  255. Pingback: europe jobs career
  256. Pingback: ny jobs career
  257. Pingback: london jobs career
  258. Pingback: live webcam girls
  259. Pingback: Kampus Ternama
  260. Pingback: 918kiss
  261. Pingback: pg slot
  262. Pingback: 918kiss
  263. Pingback: itme.xyz

发表评论